The Diabetes Mellitus is one of the hot topics in medical career, as it is widely seen among patients. But there are not just 2 types of diabetes,as you were taught in MBBS, there are 11! Below are our notes to Diabetes Mellitus to those preparing for NEET PG Exams after MBBS. Please do correct us if any, using the comments section below.
- Types of Diabetes Mellitus
- Difference between Type 1 and Type 2 Diabetes Mellitus Chart
- Antibody in Type 1 Diabetes Mellitus
- Type I Diabetes Mellitus
- Type III Diabetes Mellitus
- Type IV Diabetes Mellitus
- Potential Diabetes Mellitus
- Acute Fulminant Diabetes Mellitus
- Protein Energy Diabetes Mellitus
- LADA Diabetes Mellitus (Latent Autoimmune Diabetes of Adults)
- MODY (Maturity Onset Diabetes of the Young)
- Acute Complications of Diabetes Mellitus
- Diabetic Ketoacidosis
- New Medications of Diabetes Mellitus
- Double Diabetes – Type I DM
Diabetes Mellitus can be defined by the four criteria on basis of blood tests, which are given below:
- Fasting Blood Glucose (8 hrs) – 126 mg%
- Postprandial Blood Glucose – >200 mg% (after 2 hrs. of oral GTT: 75mg)
- Random Blood Glucose with symptoms – 200 mg%
Triad: Polyuria, Polydipsia and Weight Loss
- HbA1C > 6.5%
Best – American Diabetes Association (Average estimated glucose)
EAG – Estimated Average Glucose
Estimated Average Glucose: Conversion of % HbA1C into mg% of blood glucose is as follows:
- 6.5 % – 126 mg%
- 9.5 % – 226 mg%
Blood > Urine > PCT > Re-absorbs 1,5 Anhydroglucitol by Mannose-Fructose-1 receptor
It’s a serum used to find out hyperglycemia (at least 1 episode) in past 24 hrs.
t1/2 = 24 hrs
Normally, glucose in urine is reabsorbed by PCT via SGLT2 while 1,5-Anhydroglucitol is reabsorbed from Fructose–Mannose-1 Receptor.
SGLT-2 is inversely proportional to FM-1
Therefore, in hyperglycemia, Increase of Glucose in urine leads to increase in activity of SGLT-2. This leads to Urinary loss of 1, 5-Anhydroglucitol which results in increased activity of FM-1. Finally, it results in decreased Serum level of 1, 5-Anhydroglucitol.
Therefore, low serum level 1, 5- Anhydroglucitol is a surrogate marker of increased BG at least once in past 24 hrs.
Types of Diabetes Mellitus
There are 11 types of Diabetes Mellitus which are as follows:
- Type I DM
- Type II DM
- Type III DM
- Type IV DM
- Potential DM
- Protein Energy DM
- Acute Fulminant DM
- Tropical DM
- Double Diabetes
- MODY Diabetes
- LADA Diabetes
Difference between Type 1 and Type 2 Diabetes Mellitus Chart
The difference between Type 1 Diabetes Mellitus and Type 2 Diabetes Mellitus is give below:
|Type I DM||Type II DM|
|1. Pathogenesis||Antibody – Destruction of β cells pancreas.||Insulin receptor resistance.|
|2. Chromosome||Chromosome 6||Chromosome 2|
|3. Family History||5-15%||50-70%|
|4. HLA Association||++++
Increase in HLA-DR3
Decrease HLA-DR2 (Protective)
|6. Age of Onset||Younger
|7. Serum Insulin||Low (Insulinopenia)||Increases (Causes destruction of β cells|
|8. Complications||Diabetic Ketoacidosis||Hyperosmolar Non-Ketotic Coma|
Antibody in Type 1 Diabetes Mellitus
Usually questions asked:
- M/C – Antibody to inlet cells of pancreas.
- Anti- Insulin Antibody
- Anti – GAD (Glutamic Acid Decarboxylase) Antibody
Type I Diabetes Mellitus
Initial 1-3 Years after this, when insulin requirement is lesser than usual. (Honeymoon period of Type I Diabetes Mellitus).
Type III Diabetes Mellitus
Causes of Type 3 Diabetes Mellitus are given in the chart below:
|Drug Induced||Endocrine Defect||Alzheimer’s Dementia|
Type IV Diabetes Mellitus
Potential Diabetes Mellitus
If Single (15%) or both (40%) parents are diabetic, there’s increased chance in offspring, even though offspring may have normal Blood Glucose.
Acute Fulminant Diabetes Mellitus
- Viral Infection – HIV / EBV (Mass destruction of β cells leading to Hyperglycemia)
- Common in Pregnancy
- Reversible – in about 80% cases
Protein Energy Diabetes Mellitus
- Because of Insulin Deficiency (PEM), there is hyperglycemia
- No need of Anti-Diabetic Drugs, but just nutritional support
LADA Diabetes Mellitus (Latent Autoimmune Diabetes of Adults)
- Similar to Type I DM in Adults
- Antibodies are more but less severe autoimmune DM as compared to DM 1
- Decreased mass of β cell of pancreas
Oral Hypoglycemic drugs:
- Insulin for 2-3 Years
- Type 2 (hence one and a half Diabetes)
MODY (Maturity Onset Diabetes of the Young)
- Pathophysiology – Insulin secretion defect.
- Similar to Type II in young.
- Thin built
- HTN/CAD Risk low
- Mild Hyperglycemia
- Autosomal Dominant
There are 26 types of MODY, most common types are given below:
|MODY-3||HNF1 Alpha||Chromosome 12|
|MODY-1||HNF4 Alpha||Chromosome 20|
- Autosomal dominant
- Mild Hyperglycemia
- Age of onset – 20 to 30 Years.
- More risk of developing HTN/CAD but less as compared to type II DM.
- BMI – <25
- Auto antibodies – absent ( + only in case of LADA & Type I DM)
- MODY-3: Insulin
- MODY-1, MODY-2 & rest: OHA followed by insulin
Autosomal Dominant Polycystic Kidney Disease caused involving Chromosome 16 and Chromosome 4.
RCAD – Renal Cyst and Diabetes, meaning ADPKD + MODY-5.
Acute Complications of Diabetes Mellitus
- Diabetic Ketoacidosis (Type 1) – Hyperglycemia
Precipitating factors include Non-compliance to treatment and Infection
- Hyperosmolar Non-Ketotic Coma (Type II)
Life threatening complication of Type I DM leading to excessive Ketone body formation.
- Non compliance to Treatment.
- Fever – if infection is precipitating cause
- Acute epigastic pain repeated (Nausea/Vomiting)
- Feeble Pulse, Hypotension
- Altered sensorium in severe cases because of hyposmolality of blood
- Similar to Pancreatitis
- Blood Sugar is Greater than 400 mg%
- Serum Osmolality is 320-350 mOsmol/l
- Urinary Ketones – More
- Arterial Blood Gas – Metabolic Acidosis (In Kidney) due to Ketonuria leads to less HCO3 absorption in PCT and High anion gap.
|High Anion Gap||Normo (Chloromic 10±2)|
|DKA||Renal Tubular Acidosis|
- Na+ – Decrease in Pseudohyponatremia
- K+ – Hyperkalemia (Potassium move from Extra-cellular fluid to Intra-cellular fluid due to decreased insulin)
- Paraprotein Increases
- Cholesterol Increases
- Glucose Increases
- Multiple Myeloma
- Diabetic Ketoacidosis
- Na comes lane from Autoanalyser due to defect.
- Every 100 mg% increase in Glucose results in Decrease in 1.6mg/L in Na.
Na+ is Increased (Normal in tests after Autoanalyser) > Excessive dehydration in diabetic Ketoacidosis
K+ is Decreased > Hyperkalemia (K+ in loss of GIT Contents) and severe dehydration
Difference between Diabetic Ketoacidosis and HyperOsmolar Non-Ketotic Hyperglycemic Coma (DKA vs HONK or HHS)
|Diabetic Ketoacidosis||Hyper-Osmolar Non-Ketotic Coma|
|1. Occurs in||Type I||Type II|
|2. S. osmolality||320-350 mosm||>350 mosm|
|3. Blood Sugar||>400 mg%||>800 mg%|
|4. Expected fluid loss||4-6 L||8-10 L|
|5. Prognosis||Less dangerous||More dangerous|
- IV Fluids
Normal Saline (15-20ml/Kg/Hour for first 2-3 hrs followed by 200ml/hour till BG < 250 mg%)
- Insulin Infusion
I/V or Regular (plain)
0.15 IV/kg bolus dose followed by 0.1 IV/kg/hr flood glucose monitoring
Insulin Types: Regular, Ultra-short, Intermediate and Long Acting
- Potassium Replacement
10-20 mEq/hr K+ monitoring.
Treatment will eventually lead to hypokalemia from Hyperkalemia.
- Bicarbonate Replacement – No
Prognosis: 15-20% die even after best treatment
- Cerebral Edema (M/C of death in DKA)
- Arterial & Venous Thrombosis
Substance released from stomach in response to oral glucose which potentiate or enhance the blood sugar lowering effect of stomach.
- GIP – Gastric inhibitory peptide
- GLP Agonist – Glucagon – A peptide
Eg. – Exanitide, Liraglutide
- Most common – Nausea/Vomiting
- Weight Loss – severe
- Bladder Cancer (Most dangerous)
Endogenous GLP-1 is converted to by-products through DPP 4. These Gliptan drugs prevent degradation of GLP-1 by inhibiting DPP 4, hence more availability of GLP-1 and decrease in blood sugar.
Examples: Sitagliptin, Saxagliptin, Vildagliptin, Linagliptin, Alogliptin
New Medications of Diabetes Mellitus
Given below are the newer drugs for DM:
- Resveratrol – Anti-oxidant – decreases 20X doses antioxidant properly
- Colesevelam – bile and sequestrant
- Pramlintide (in both type 1 & 2) – Amylin analog – decreases glucagon levels in body causing hypoglycemia
- Fasiglifam– a free fatty acid Receptor Agonist. It’ll increase insulin secretion. FFAR-1 acts on beta cells.
Double Diabetes – Type I DM
Insulin requirement is increased in Insulin resistance (Type II DM). In patients of Type I DM, upon 5-8 years of onset, there is development of insulin resistance, i.e, feature of Type II DM, hence labelled as Double Diabetes.